| Product Name | Collagen Type XVII antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse Monoclonal antibody [B1052M] to Collagen Type XVIIThis gene encodes the alpha chain of type XVII collagen. Unlike most collagens, collagen XVII is a transmembrane protein. Collagen XVII is a structural component of hemidesmosomes, multiprotein complexes at the dermal-epidermal basement membrane zone that mediate adhesion of keratinocytes to the underlying membrane. Mutations in this gene are associated with both generalized atrophic benign and junctional epidermolysis bullosa. Two homotrimeric forms of type XVII collagen exist. The full length form is the transmembrane protein. A soluble form, referred to as either ectodomain or LAD-1, is generated by proteolytic processing of the full length form. [provided by RefSeq] |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG2a |
| Clone Number | B1052M |
| Host Species | Mouse |
| Tested Applications | ELISAIHC-FWB |
| IHC-F:1:50~1:100 WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | BA16H23.2 BP180 BPAG2 KIAA0204 LAD-1 |
|---|---|
| Target | Collagen Type XVII |
| Tissue Specificity | Collagen Type XVII |
| Cellular Localization | Localized along the plasma membrane of the hemidesmosome. Exclusively localized to anchoring filaments. Localized to the epidermal side of split skin. Localized in the lamina lucida beneath the hemidesmosomes. |
| Application Notes | IHC-F:1:50~1:100 WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Upon receipt, store at –20°C. Avoid multiple freeze/thaw cycles. |
| Storage Buffer | Lyophilized from 50 mM Tris, pH 7.4. |
