| Product Name | COX1 antibody [AS70] |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal [AS70] to COX1 / Cyclooxygenase 1Cyclooxygenase (COX), also known as Prostaglandin H2 synthase and Prostaglandin endoperoxide synthase, is a key enzyme in the of conversion arachidonic acid to Prostaglandin H2. Prostaglandin H2 is converted by other enzymes into inflammatory mediators prostaglandin (PG) D2, PGE2, PGF2a, PGI2 and Thromboxane A2. Thus, COX is a key enzyme in the production of inflammatory agents and is the target of intense research and drug discovery activities. There are two enzymes of COX, COX-1 and COX-2. COX-1 is constitutively produced in many (most) cell types. It is important in the gut for the production of prostaglandins, which inhibit gastric secretion. It can be induced in monocytes, macrophages and other cells. It is induced as part of the inflammatory response by IL-1beta and other cytokines. It is induced by growth factors such as EGF and PDGF. Expression is inhibited by glucocorticosteroids such as cortisol and dexamethasone. Lipopolysaccharide in bacterial infections induces COX-2. COX-2 is also found in elevated levels in synoviocytes from rheumatoid arthritis patients. The discomforts of inflammation such as pain and swelling are largely due to the action of prostaglandins produced by COX-2. |
| Immunogen | Unfortunately, this information is considered to be commercially sensitive |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | AS70 |
| Host Species | Mouse |
| Tested Applications | EIA |
| EIA: Use at an assay dependent dilution. Optimal dilutions/concentrations should be determined by the end user. | |
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Unpurified |
| Gene Synonyms | PCOX1, 176805, PGHS1, PGHS-1, PGG/HS, P23219, PHS1, COX1, PTGS1, 5742, PTGHS, COX3, PGHS 1 |
|---|---|
| Target | COX1 |
| Cellular Localization | Cytoplasmic |
| Application Notes | EIA: Use at an assay dependent dilution. Optimal dilutions/concentrations should be determined by the end user. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles. |
| Storage Buffer | Preservative: 0.08% Sodium Azide; Constituents: PBS |
