Application
IHC-Fr ImageIHC analysis of KChIP3 in frozen sections of mouse brain extract using .| Product Name | CSEN antibody [S66-38] |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal antibody [S66-38] to CSENCalcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception. Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Probably modulates channels density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents (By similarity). Involved in KCND2 and probably KCND3 trafficking to the cell surface. May play a role in the regulation of PSEN2 proteolytic processing and apoptosis. Together with PSEN2 involved in modulation of beta-amyloid formation. |
| Immunogen | Fusion protein amino acids 1-256 (Full lenght) of rat CSEN. |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG2a |
| Clone Number | S66-38 |
| Host Species | Mouse |
| Tested Applications | IHCIHC-FIPWB |
| We recommend a working dilution of 1ug/mL (WB), 0.1-1ug/mL (IHC/ICC), 1-10ug/mL (IF). | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml (Please refer to the vial label for the specific concentration) |
| Purification | Protein G |
| Gene Synonyms | rKChIP3, Kcnip3, Csen, Dream |
|---|---|
| Target | CSEN |
| Molecular Weight(MW) | 34kDa (note) |
| Tissue Specificity | No cross reactivity against KCIPs 1,2 or 4 |
| Cellular Localization | In the presence of PSEN2 associated with the endoplasmic reticulum and Golgi. |
Application
IHC-Fr ImageIHC analysis of KChIP3 in frozen sections of mouse brain extract using .| Application Notes | We recommend a working dilution of 1ug/mL (WB), 0.1-1ug/mL (IHC/ICC), 1-10ug/mL (IF). |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Aliquot and store at -20 C. Avoid repeated freeze-thaw cycles. |
| Storage Buffer | PBS pH7.4, 50% glycerol |
