Rabbit Polyclonal antibody to Cullin 3This gene encodes a member of the cullin protein family. The encoded protein plays a critical role in the polyubiquitination and subsequent degradation of specific protein substrates as the core component and scaffold protein of an E3 ubiquitin ligase complex. Complexes including the encoded protein may also play a role in late endosome maturation. Mutations in this gene are a cause of type 2E pseudohypoaldosteronism. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
Immunogen
Recombinant protein of human CUL3
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
IHCIHC-PWB
WB: 1:200 - 1:1000. IHC: 1:50 - 1:100:
Species Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Gene Synonyms
cullin 3 PHA2E CUL3
Target
Cullin 3
Application
Application
Western blot analysis of extracts of 293T cell line, using CUL3 antibody.
Application
Immunohistochemistry of paraffin-embedded human lung cancer tissue using CUL3 antibody.