| Product Name | Cytochrome P450 3A4 + 3A5 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal antibody [F24 P2 B10] to Cytochrome P450 3A4 + 3A5This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Feb 2011] |
| Immunogen | Synthetic peptide corresponding to residues E S R D G T V S G A, conjugated to ovalbumin. |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | F24 P2 B10 |
| Host Species | Mouse |
| Tested Applications | IHCWB |
| WB: 1:500 Optimal dilution / concentration should be determined by the end user.: |
|
| Species Reactivity | HumanBovine |
| Concentration | 1mg/ml |
| Gene Synonyms | CYPIIIA3 cytochrome P450 family 3 subfamily A polypeptide 4 P450C3 CYP3A4 P450PCN1 CYP3A CYPIIIA4 CP34 CP33 NF-25 HLP CYP3A3 Antibo |
|---|---|
| Target | Cytochrome P450 3A4, 3A5 |
| Application Notes | WB: 1:500 Optimal dilution / concentration should be determined by the end user.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | -20° C, Avoid Freeze/Thaw Cycles |
| Storage Buffer | Ascites containing 0.05 % sodium azide |
