| Product Name | Cytokeratin 13 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Monoclonal Mouse Antibody to Human Cytokeratin 13The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This type I cytokeratin is paired with keratin 4 and expressed in the suprabasal layers of non-cornified stratified epithelia. Mutations in this gene and keratin 4 have been associated with the autosomal dominant disorder White Sponge Nevus. The type I cytokeratins are clustered in a region of chromosome 17q21.2. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been described. [provided by RefSeq] |
| Immunogen | Cultured A431 cells from a human epidermoid carcinoma of the vulva. |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | KS-1A3 |
| Host Species | Mouse |
| Tested Applications | IHC-P |
| This antibody may be diluted to a titer of 1:25 to 1:100 in an ABC method. However, depending on the staining conditions employed, we suggest that final dilution should be determined by the user.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | Cytokeratin 13 KRT13 Cytokeratin13 MGC3781 148065 P13646 3860 CK13 K13 MGC161462 |
|---|---|
| Target | Cytokeratin 13 |
| Tissue Specificity | This antibody is specific to 54 kD protein. Cytokeratin 13 belongs to the type A (acidic) subfamily of low molecular weight cytokeratins and exists in combination with cytokeratin 4. Cytokeratin 13 is expressed in major component of squamous, non-keratinized epithelium, transitional epithelium and myoepithelium. This antibody is useful for the identification of carcinomas of trachea, sweat glands, bladder, ectocervix, tongue, esophagus, anal canal and the basal layer of keratinized epidermis. |
| Cellular Localization | Cytoplasmic |
| Positive Control | Skin |
|---|---|
| Application Notes | This antibody may be diluted to a titer of 1:25 to 1:100 in an ABC method. However, depending on the staining conditions employed, we suggest that final dilution should be determined by the user.: |
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution, aliquot and store at 4°C. Do not freeze. |
| Storage Buffer | The antibody is supplied in |
