| Product Name | Cytokeratin 5/6/18 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal antibody [LP34] to Cytokeratin 5/6/18The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. This KRT6 gene in particular encodes the most abundant isoform. Mutations in these genes have been associated with pachyonychia congenita. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008] |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | LP34 |
| Host Species | Mouse |
| Tested Applications | IHC-FIHC-P |
| Immunohistology - Frozen: Max Dilution 1/100: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | K6D K6C CK6C K6A KRT6C KRT6A KRT6D CK6A CK6D |
|---|---|
| Target | Cytokeratin 5, 6 + 18 |
| Tissue Specificity | This antibody recognizes human cytokeratins 5, 6 and 18. |
| Application Notes | Immunohistology - Frozen: Max Dilution 1/100: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4°C or at -20°C if preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
