| Product Name | Cytokeratin 6 + 18 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal [LP34] to Cytokeratin 6+18The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. This KRT6 gene in particular encodes the most abundant isoform. Mutations in these genes have been associated with pachyonychia congenita. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq] |
| Immunogen | Human stratum corneum |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | LP34 |
| Host Species | Mouse |
| Tested Applications | AFIHC-FIHC-PWB |
| AF: Use at an assay dependent dilution. IHC-P: Use at an assay dependent dilution. IHC-Fr: Use at an assay dependent dilution. WB: Use at an assay dependent dilution. Predicted molecular weight: 59 & 48 kDa respectively. Optimal dilutions/concentrations should be determined by the end user.: |
|
| Species Reactivity | Human |
| Concentration | 0.5mg/ml |
| Purification | Protein A |
| Gene Synonyms | KRT6B P04259 P02538 KRT18 Cytokeratin 6 + 18 148041 Cytokeratin6 + 18 K18 CYK18 3853 K6A PC2 148042 K6B 3854 P05783 CK6B KRT6A CK6A 3875 KRTL1 148070 |
|---|---|
| Target | Cytokeratin 6 + 18 |
| Tissue Specificity | Stains all human epithelial cells except for the inner hair root sheath and one or two other exceptional cell types. Does not react significantly with Keratins 1, 8 and 19. |
| Cellular Localization | Cytoplasmic |
| Light Chain Type | kappa |
| Positive Control | Normal skin |
|---|---|
| Application Notes | AF: Use at an assay dependent dilution. IHC-P: Use at an assay dependent dilution. IHC-Fr: Use at an assay dependent dilution. WB: Use at an assay dependent dilution. Predicted molecular weight: 59 & 48 kDa respectively. Optimal dilutions/concentrations should be determined by the end user.: |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at 4°C. Long term (>6months) aliquot and store at -20°C. Avoid repeated freeze thawing. |
| Storage Buffer | Phosphate buffered saline |
