Rabbit polyclonal antibody to DcR1The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL. [provided by RefSeq, Jul 2008]
Immunogen
Synthetic peptide corresponding to amino acids 149 to 157 within the extracellular domain of human DcR1.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WB
Western Blotting: 1/500 - 1/1000 Optimal dilution / concentration should be determined by the end user.:
Species Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Gene Synonyms
CD263 DCR1-TNFR DCR1 TRID TNFRSF10C LIT TRAILR3
Target
DcR1
Tissue Specificity
This antibody is specific for human CD263, also known as TRAIL-R3 and DcR1.
Application
Application
WB analysis of HeLa cell lysate using DcR1 antibody.
Application Notes
Western Blotting: 1/500 - 1/1000 Optimal dilution / concentration should be determined by the end user.:
Additional Information
Form
Liquid
Storage Instructions
Store at +4°C or at -20°C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.