Rabbit Polyclonal antibody to DcR1The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL. [provided by RefSeq, Jul 2008]
Immunogen
Recombinant protein of human TNFRSF10C
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
IHC-PWB
WB: 1:500 - 1:2000, IHC: 1:50 - 1:200:
Species Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Gene Synonyms
LIT TRAILR3 TNFRSF10C DCR1 tumor necrosis factor receptor superfamily member 10c DCR1TNFR TRAIL R3 TRID CD263
Target
DcR1
Application
Application
Western blot analysis of human spleen cell lysate using TNFRSF10C antibody.