| Product Name | Desmoglein 1 antibody [3G131] |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal [3G131] to Desmoglein 1Desmosomes are cell-cell junctions between epithelial, myocardial and certain other cell types. Desmoglein 1 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. Desmoglein 1 has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus foliaceus. |
| Immunogen | Intracellular domain of Desmoglein 1 (Human). |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | 3G131 |
| Host Species | Mouse |
| Tested Applications | ICC/IFIHC-FIPWB |
| For IF: Use at an assay dependent dilution. For IHC-Fr: Use at a concentration of 20-50 μg/ml. For IP: Use at a concentration of 5-10 μg/ml. For WB: Use at a concentration of 1-3 μg/ml. Optimal dilutions/concentrations should be determined by the researcher. | |
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Protein A |
| Gene Synonyms | 125670, Q02413, CDHF4, DG1, Desmoglein 1, Desmoglein1, DSG1, 1828, DSG |
|---|---|
| Target | Desmoglein 1 |
| Tissue Specificity | This antibody does not cross-react with Desmoglein 2 or Desmoglein 3. |
| Cellular Localization | Cell Membrane |
| Positive Control | Differentiated keratinocytes and Desmoglein 1 transfected cells |
|---|---|
| Application Notes | For IF: Use at an assay dependent dilution. For IHC-Fr: Use at a concentration of 20-50 μg/ml. For IP: Use at a concentration of 5-10 μg/ml. For WB: Use at a concentration of 1-3 μg/ml. Optimal dilutions/concentrations should be determined by the researcher. |
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles. |
| Storage Buffer | Phosphate-buffered saline, pH 7.2, containing 0.1% sodium azide |
