| Product description |
Mouse Anti-Diphtheria toxin Monoclonal AntibodyCorynebacterium diphtheriae infects the nasopharynx or skin, multiplying and secreting diphtheria toxin in nasopharyngeal or skin lesions. The diphtheria toxin is exceptionally potent with as little as 100-150 ng/kg of body weight being a lethal dose in susceptible individuals. Diphtheria toxin expression is under the control of an iron-activated repressor, DtxR. The dissociation of iron and DtxR under low iron conditions activates the tox gene, leading to its synthesis and secretion. |