Rabbit polyclonal antibody to DR6The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB and MAPK8/JNK, and induce cell apoptosis. Through its death domain, this receptor interacts with TRADD protein, which is known to serve as an adaptor that mediates signal transduction of TNF-receptors. Knockout studies in mice suggested that this gene plays a role in T-helper cell activation, and may be involved in inflammation and immune regulation. [provided by RefSeq, Jul 2008]
Immunogen
Peptide corresponding to amino acids 42-56 of human DR6 precursor.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WB
Western Blotting: Max Dilution 1/500 Optimal dilution / concentration should be determined by the end user.:
Species Reactivity
Human
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Gene Synonyms
BM-018 TNFRSF21 tumor necrosis factor receptor superfamily member 21 CD358
Application
Application
WB analysis of K562 (1,3) and Raji (2,4) cell lysate using DR6 antibody in the absence (1,2) or presence (3,4) of blocking peptide
Application Notes
Western Blotting: Max Dilution 1/500 Optimal dilution / concentration should be determined by the end user.:
Additional Information
Form
Liquid
Storage Instructions
Store at +4°C. This product should be stored undiluted. DO NOT FREEZE. Should this product contain a precipitate we recommend microcentrifugation before use.