Application
Western blot analysis of 30 µg of total cell lysate from Jurkat (lane 1), HeLa (lane 2), and Daudi (lane 3) cells with IMG-166 at 2 µg/ml.| Product Name | DR6 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal to DR6Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. Several novel death receptors including DR3, DR4, and DR5 were recently identified. A new death domain containing receptor in the TNFR family was cloned recently and termed DR6 for death receptor 6. Like TNFR1, DR6 interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-kB and JNK. DR6 is widely expressed inhuman tissues and cell lines. The ligand for DR6 hasnot been identified. |
| Immunogen | Synthetic peptide, corresponding to amino acids 371 - 655 of Human DR6. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG2 |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB: Use at a concentration of 2 - 4 μg/ml. Detects a band of approximately 66 kDa (predicted molecular weight: 79 kDa). Optimal dilutions/concentrations should be determined by the end user.: |
|
| Species Reactivity | Human |
| Concentration | 0.2mg/ml |
| Purification | Protein A |
| Gene Synonyms | 27242 BM-018 O75509 605732 TNFRSF21 MGC31965 BM018 DR6 BM 018 |
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Application
Western blot analysis of 30 µg of total cell lysate from Jurkat (lane 1), HeLa (lane 2), and Daudi (lane 3) cells with IMG-166 at 2 µg/ml.| Application Notes | WB: Use at a concentration of 2 - 4 μg/ml. Detects a band of approximately 66 kDa (predicted molecular weight: 79 kDa). Optimal dilutions/concentrations should be determined by the end user.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles. |
| Storage Buffer | Preservative: 0.02% Sodium Azide; Constituents: PBS |
