Rabbit monoclonal antibody [EPR3163Y] to DRAK2DRAK2 belongs to a family of novel serine/threonine kinases whose catalytic domains are related to that of death-associated protein kinase involved in apoptosis. DRAK2 is composed of an N-terminal catalytic domain and a C-terminal domain that is responsible for regulation of kinase activity. DRAK2 is exclusively localized to the nucleus and overexpression of DRAK2 induces the morphological changes of apoptosis in NIH 3T3 cells, suggesting the role of DRAK2 in apoptotic signaling.
Immunogen
A synthetic peptide corresponding to residues 200 - 300 aa in human DRAK2 was used as an immunogen.
Key Feature
Clonality
Monoclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
ICC/IFIPWB
Not yet tested in other applications. Optimal dilutions should be determined experimentally by the end user.:
Species Reactivity
HumanMouse
Concentration
1mg/ml
Target Information
Gene Synonyms
DRAK2
Application
Application
Western blot analysis on (A) Jurkat +TPA (B) Ramos and (C) Ramos+TPA cell lysates using anti-DRAK2 rabbit mAb (cat. #).
Application Notes
Not yet tested in other applications. Optimal dilutions should be determined experimentally by the end user.:
Additional Information
Form
Liquid
Storage Instructions
Store at -20 °C. Stable for 12 months from date of receipt.
Storage Buffer
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.