Mouse monoclonal [F-343] to FGF basicFGF family members bind heparin and possess broad mitogenic and angiogenic activities. FGF is involved in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. FGF mRNA contains multiple polyadenylation sites, and is alternatively translated from AUG and non-AUG (CUG) initiation codons resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF.
Immunogen
Full length native protein (purified) (Human).
Key Feature
Clonality
Monoclonal
Isotype
IgG1
Clone Number
F-343
Host Species
Mouse
Tested Applications
ELISAWB
ELISA: Use at an assay dependent dilution. Optimal dilutions/concentrations should be determined by the end user.
Species Reactivity
Human
Concentration
1mg/ml (Please refer to the vial label for the specific concentration)