| Product Name | FGFR1 antibody [M1C4] |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal antibody [M1C4] to FGFR1The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq] |
| Immunogen | Recombinant human ectodomain of FGFr1a expressed in E. coli beginning with pro23; antigen contained NH2-terminal gly-ser-pro-gly-ile and COOH-terminal glu-phe sequences. |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | M1C4 |
| Host Species | Mouse |
| Tested Applications | IPWB |
| Western blotting: at 1 ug/ml recognizes 10 ng recombinant bacterial, baculo-viral, or native FGFr1.Immunoprecipitation: Ig loop I fragment of denatured, intact FGFr1a.Immunohistochemistry: untested predicted to be poor due to masked epitope. | |
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Protein G |
| Gene Synonyms | CEK, CFGR, N-SAM, H5, NSAM, FLT2, P11362, FGFR1 alpha, BFGFR, 2260, FLG, H3, KAL2, H2, H4, FGFR1, 101600, C-FGR, N SAM, C FGR |
|---|---|
| Target | FGFR1 |
| Tissue Specificity | Reacts with alpha isoform of FRFR1. |
| Application Notes | Western blotting: at 1 ug/ml recognizes 10 ng recombinant bacterial, baculo-viral, or native FGFr1.Immunoprecipitation: Ig loop I fragment of denatured, intact FGFr1a.Immunohistochemistry: untested predicted to be poor due to masked epitope. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid freeze-thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide |
