| Product Name | FK506 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal [FK1] to FK506FK 506 antigen is a novel macrolide with similar but more potent immunosuppressant activity than cyclosporine. FK 506 is used for primary or rescue immunosuppression in patients after solid organ transplantation. Clinically relevant FK506 side effects are nephrotoxicity, neurotoxicity, diabetes mellitus and hypertension. Most of these side effects are more closely related to FK 506 blood levels than dosage; therefore therapeutic drug monitoring (TDM) of FK506 levels is a prerequisite for therapy. Whole blood is the matrix of choice for FK 506 TDM. The whole blood target level range aimed for in clinical practice is between 3.0 and 20.0 ng/ml and depends on the patient's liver function, the type of organ transplanted and the time after transplantation. |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgM |
| Clone Number | FK1 |
| Host Species | Mouse |
| Tested Applications | ELISAWB |
| WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Concentration | 1mg/ml |
| Target | FK506 |
|---|---|
| Tissue Specificity | Recognizes conjugated and non-conjugated FK-506 with apparent dissociation constant Kd=10 -9 M. |
| Application Notes | WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution, aliquot and store at 4°C. Do not freeze. We recommend to parafilm vials during storage to prevent evaporation of buffer. |
| Storage Buffer | 50 mM Tris/HCl, 150 mM NaCl, pH 8.0 containing 0.1% of sodium azide as preservative. |
