Application
Immunohistochemistry of FRMPD2 in mouse kidney tissue with FRMPD2 antibody at 5 ug/ml.Application
Western blot analysis of FRMPD2 in rat kidney tissue lysate with FRMPD2 antibody at (A) 1 and (B) 2 ug/ml.| Product Name | FRMPD2 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal antibody to FRMPD2The FERM and PDZ domain containing (FRMPD) protein family consists of four proteins that contain a FERM (Four-point-one, erzin, radixin, moesin) domain and at least one PDZ (PSD-95/Discs large/Zonula-occuldens-1) domain. FRMPD2 also contains an N-terminal KIND domain and three PDZ domains and is structurally similar to the protein tyrosine phosphatase PTP-BL (4). FRMPD2 is localized in a polarized fashion in epithelial cells at the basolateral membrane and partially co-localizes with the tight-junction marker protein Zonula-occuldens-1. Suppression of FRMPD2 expression via RNAi in Caco-2 cells results in an impairment of tight junction formation, indicating that FRMPD2 plays a major role in tight junction formation. Other experiments indicate that FRMPD2 is a binding partner to several catenin family members and recruitment of FRMPD2 to cell-cell contacts is dependent on E-cadherin-mediated cell-cell adhesion. |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | ELISAIHC-PWB |
| IHC-P:1:50~1:200 WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | FERM and PDZ domain-containing 2 PDZK5C FERM and PDZ domaincontaining 2 FERM and PDZ domaincontaining2 FRMPD2 PDZD5C |
|---|---|
| Target | FRMPD2 |
| Tissue Specificity | This antibody is specific for FRMPD2 |
Application
Immunohistochemistry of FRMPD2 in mouse kidney tissue with FRMPD2 antibody at 5 ug/ml.
Application
Western blot analysis of FRMPD2 in rat kidney tissue lysate with FRMPD2 antibody at (A) 1 and (B) 2 ug/ml.| Positive Control | Blocking Peptide: Cat.No. GTX85236-PEP - FRMPD2 Peptide Lysates: Cat. No. GTX27944 - Rat Kidney Tissue Lysate |
|---|---|
| Application Notes | IHC-P:1:50~1:200 WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | PBS containing 0.02% sodium azide |
