Rabbit polyclonal antibody to FTSThe mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. The protein encoded by this gene is similar to the ubiquitin ligase domain of other ubiquitin-conjugating enzymes but lacks the conserved cysteine residue that enables those enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine/threonine kinase protein kinase B (PKB)/Akt and modulates PKB activity by enhancing the phosphorylation of PKB's regulatory sites. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Immunogen
Recombinant protein of human AKTIP
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
IHC-PWB
WB: 1:500 - 1:2000. IHC: 1:50 - 1:200.:
Species Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Gene Synonyms
FT1 AKT interacting protein AKTIP
Target
FTS
Molecular Weight(MW)
33 kDa (note)
Application
Application
WB analysis of extracts from various cell lines using FTS antibody.
Application Notes
WB: 1:500 - 1:2000. IHC: 1:50 - 1:200.:
Additional Information
Form
Liquid
Storage Instructions
Store at -20°C (regular) or -80°C (long term). Avoid freeze / thaw cycles.