| Product Name | GAD65 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse Monoclonal antibody [144] to NGAD65This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq] |
| Immunogen | Peptide corresponding to human GAD65 amino acids 4-22, coupled to KLH |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | 144 |
| Host Species | Mouse |
| Tested Applications | FACSIHCIPWB |
| For WB: Use at 1µg/mL: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml (Please refer to the vial label for the specific concentration) |
| Purification | Affinity purified |
| Gene Synonyms | 65 kDa glutamic acid decarboxylase antibody DCE 2 antibody DCE2 antibody GAD 2 antibody GAD 65 antibody GAD-2 antibody GAD-65 antibody GAD2 antibody Glutamate Decarboxylase 2 (pancreatic islets and brain 65kDa) antibody Glutamate Decarboxylase 2 a |
|---|---|
| Target | GAD65 |
| Tissue Specificity | GAD65 (human, mouse and rat, other specificities not tested) |
| Cellular Localization | Associated to cytoplasmic vesicles. In neurons, cytosolic leaflet of Golgi membranes and presynaptic clusters. |
| Application Notes | For WB: Use at 1µg/mL: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at 2-8°C. For extended storage, aliquot and store at -20°C. Avoid repeated freeze-thaw cycles. |
| Storage Buffer | PBS + 0.1% sodium azide |
