Application
Sample(30 ug whole cell lysate) A:293T B:H1299 10% SDS PAGE diluted at 1:1000Application
Immunohistochemical analysis of paraffin-embedded human skin, using Galanin Receptor 2 antibody(10 μg/ml).| Product Name | Galanin Receptor 2 antibody , Internal |
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| Antibody Type | Primary Antibodies |
| Product description | Rabbit Polyclonal antibody to Galanin Receptor 2 (galanin receptor 2)Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the galanin peptide. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi. However, it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simultaneously activate 2 independent signal transduction pathways. [provided by RefSeq] |
| Immunogen | Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human Galanin Receptor 2. The exact sequence is proprietary. |
| Clonality | Polyclonal |
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| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IHC-PWB |
| *Optimal dilutions/concentrations should be determined by the researcher.
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| Species Reactivity | Human |
| Predicted Reactivity | Mouse, Rat, BovineMouse (94%), Rat (94%), Bovine (94%) |
| Concentration | 1mg/ml (Please refer to the vial label for the specific concentration) |
| Purification | Affinity purified |
| Gene Synonyms | GALNR2 antibody MGC125983 antibody MGC125984 antibody GALR2 antibody GALR-2 antibody GAL2-R antibody galanin receptor type 2 antibody galanin receptor 2 antibody |
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| Molecular Weight(MW) | 42 kDa (note) |
| Cellular Localization | Cell membrane; Multi-pass membrane protein |
Application
Sample(30 ug whole cell lysate) A:293T B:H1299 10% SDS PAGE diluted at 1:1000
Application
Immunohistochemical analysis of paraffin-embedded human skin, using Galanin Receptor 2 antibody(10 μg/ml).| Positive Control | 293T , A431 , H1299 , HeLaS3 , HepG2 , Molt-4 , Raji |
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| Application Notes | *Optimal dilutions/concentrations should be determined by the researcher.
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| Form | Liquid |
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| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative. |
