Application
Western blot detection of GCAP1 in bovine rod outer segment lysate.| Product Name | GCAP1 antibody [G2] |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal antibody [G2] to GCAP1This gene plays a role in the recovery of retinal photoreceptors from photobleaching. In the recovery phase, the phototransduction messeneger cGMP is replenished by retinal guanylyl cyclase-1 (GC1). GC1 is activated by decreasing Ca(2+) concentrations following photobleaching. The protein encoded by this gene, guanylyl cyclase activating protein 1 (GCAP1), mediates the sensitivity of GC1 to Ca(2+) concentrations. GCAP1 promotes activity of GC1 at low Ca(2+) concentrations and inhibits GC1 activity at high Ca(2+) concentrations. Mutations in this gene cause autosomal dominant cone dystrophy (COD3); a disease characterized by reduced visual acuity associated with progressive loss of color vision. Mutations in this gene prohibit the inactivation of RetGC1 at high Ca(2+) concentrations; causing the constitutive activation of RetGC1 and, presumably, increased cell death. This gene is expressed in retina and spermatagonia. [provided by RefSeq, Feb 2009] |
| Immunogen | Bacterial expressed full length GCAP-1. |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG2a |
| Clone Number | G2 |
| Host Species | Mouse |
| Tested Applications | BlockingIPWB |
| Blocking: 50 ug/ml | |
| Species Reactivity | HumanPrimateBovine |
| Concentration | 1mg/ml (Please refer to the vial label for the specific concentration) |
| Purification | Affinity purified |
| Gene Synonyms | GUCA1A , GUCA , C6orf131 , GCAP , COD3 , guanylate cyclase activator 1A (retina) , dJ139D8.6 , GUCA1 , CORD14 |
|---|---|
| Target | GCAP1 |
| Tissue Specificity | This antibody is specific for GCAP-1 and does not react with other isotypes. |
Application
Western blot detection of GCAP1 in bovine rod outer segment lysate.| Application Notes | Blocking: 50 ug/ml |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | -20° C, Avoid Freeze/Thaw Cycles |
| Storage Buffer | PBS containing 0.05 % sodium azide and 1 mg/ml BSA |
