| Product Name | GDNF antibody [12F9] |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal antibody [12F9] to GDNFThis gene encodes a highly conserved neurotrophic factor. The recombinant form of this protein was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. The encoded protein is processed to a mature secreted form that exists as a homodimer. The mature form of the protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene may be associated with Hirschsprung disease. [provided by RefSeq, Jun 2010] |
| Immunogen | Human recombinant GDNF |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG2 |
| Clone Number | 12F9 |
| Host Species | Mouse |
| Tested Applications | NeutWBFunctional Assay |
| WB(1:500-1000)|Neutralization of GDNF bioactivity | |
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | HFB1-GDNF , ATF1 , HSCR3 , glial cell derived neurotrophic factor , ATF2 |
|---|---|
| Target | GDNF |
| Tissue Specificity | This antibody was selected for its ability to detect human GDNF. |
| Application Notes | WB(1:500-1000)|Neutralization of GDNF bioactivity |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | PBS |
