Application
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Girdin (Phospho-Ser1417) antibody (left) or the same antibody preincubated with blocking peptide (right).| Product Name | Girdin (phospho Ser1417) antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit Polyclonal antibody to Girdin (phospho Ser1417)This gene encodes a member of the Girdin family of coiled-coil domain containing proteins. The encoded protein is an actin-binding protein that is activated by the serine/threonine kinase Akt and plays a role in cytoskeleton remodeling and cell migration. The encoded protein also enhances Akt signaling by mediating phosphoinositide 3-kinase (PI3K)-dependent activation of Akt by growth factor receptor tyrosine kinases and G protein-coupled receptors. Increased expression of this gene and phosphorylation of the encoded protein may play a role in cancer metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011] |
| Immunogen | Peptide sequence around phosphorylation site of Serine 417(Q-K-S(p)-L-T) derived from Human Girdin . |
| Modification | p-Ser1417 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IHC-P |
| IHC: 1:50 - 1:100: |
|
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml (Please refer to the vial label for the specific concentration) |
| Purification | Affinity purified |
| Gene Synonyms | APE HkRP1 GIV KIAA1212 coiled-coil domain containing 88A CCDC88A GIRDIN GRDN |
|---|---|
| Target | Girdin (phospho Ser1417) |
| Tissue Specificity | The antibody detects endogenous levels of Girdin only when phosphorylated at serine 1417. |
Application
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Girdin (Phospho-Ser1417) antibody (left) or the same antibody preincubated with blocking peptide (right).| Application Notes | IHC: 1:50 - 1:100: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at -20˚C/1 year |
| Storage Buffer | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
