| Product Name | GnRHR antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal antibody [A9E4] to GnRHRThis gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gene. [provided by RefSeq, Jul 2008] |
| Immunogen | Synthetic peptide corresponding to the amino acids 1 - 29 of the human luteinizing hormone releasing hormone receptor extracellular domain conjugated to Bovine Serum Albumin. |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | A9E4 |
| Host Species | Mouse |
| Tested Applications | ELISAFACSIHC-FWB |
| FACS:1:200~1:500 IHC-F:1:50~1:100 WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | GNRHR GRHR LRHR GNRHR1 LHRHR HH7 |
|---|---|
| Target | Luteinizing Hormone Releasing Hormone Receptor |
| Tissue Specificity | This antibody recognizes human luteinizing hormone releasing hormone receptor (human GnRH receptor). |
| Application Notes | FACS:1:200~1:500 IHC-F:1:50~1:100 WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4°C or at -20°C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. |
| Storage Buffer | Phosphate buffered saline containing 0.09% Sodium Azide (NaN3) |
