Application
Flow cytometry analysis of human CD8+ peripheral blood cells with anti-human granzyme B: PE| Product Name | Granzyme B antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse Monoclonal antibody [CLB-GB11] to Granzyme BGranzyme B is a serine protease that is expressed in cytoplasmic granules of cytotoxic T lymphocytes and NK cells. Vectorial secretion of perforin and granzymes is responsible for their granule-mediated cytotoxicity. Granzyme B plays a pivotal role in the induction of apoptosis in the target cells by activation of caspases. Moreover, granzyme B was reported to cleave directly alpha-tubulin, leading to perturbation of microtubule networks during the induced cell death.Entrez Gene: 14q11.2 |
| Immunogen | Human NK cell line YT-INDY-derived granzyme B |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | CLB-GB11 |
| Host Species | Mouse |
| Tested Applications | FACS |
| Optimal dilutions should be determined experimentally by the researcher.: |
|
| Species Reactivity | HumanPrimate |
| Concentration | 1mg/ml |
| Target | Granzyme B |
|---|---|
| Tissue Specificity | The mouse monoclonal antibody CLB-GB11 recognizes granzyme B, a 31 kDa serine protease expressed in activated Tc cells and NK cells. |
Application
Flow cytometry analysis of human CD8+ peripheral blood cells with anti-human granzyme B: PE| Application Notes | Optimal dilutions should be determined experimentally by the researcher.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at 2-8°C. Do not use after expiration date stamped on vial label. For long-term storage aliquot and store at -20°C. Avoid freeze/thaw cycles. |
| Storage Buffer | Tris buffered saline (TBS) with 15 mM sodium azide, approx. pH 8.0 |
