Application
Immunofluorescence of HAAO in Human Liver cells with HAAO antibody at 20 ug/mL.| Product Name | HAAO antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal antibody to HAAOHAAO (3-Hydroxyanthranilate 3,4-dioxygenase) is a monomeric cytosolic protein of the family of intramolecular dioxygenases containing non-heme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is present in low amounts in the central nervous system. This enzyme participates in tryptophan metabolism. It employs one cofactor, iron. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurological and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. Furthermore, recent study shows that HAAO are excellent candidate biomarkers for detecting ovarian cancer. |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | ELISAICC/IFIHC-P |
| ICC/IF:1:200~1:500 IHC-P:1:50~1:200 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | 3hydroxyanthranilate 3 HAD HAAO 3hydroxyanthranilate oxygenase 4-dioxygenase 3-HAO 3HAO 3-hydroxyanthranilate 3 4dioxygenase HAO 3-hydroxyanthranilate oxygenase 3hydroxyanthranilate3 3 HAO 4 dioxygenase 3 hydroxyanthranilate 3 |
|---|---|
| Target | HAAO |
| Tissue Specificity | This antibody is specific for HAAO |
Application
Immunofluorescence of HAAO in Human Liver cells with HAAO antibody at 20 ug/mL.| Positive Control | Blocking Peptide: Cat.No. GTX85015-PEP - HAAO Peptide Lysates: Cat. No. GTX27935 - Mouse Liver Tissue Lysate |
|---|---|
| Application Notes | ICC/IF:1:200~1:500 IHC-P:1:50~1:200 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Antibody is supplied in PBS containing 0.02% sodium azide |
