Mouse monoclonal antibody [S71-37] to HCN2Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Produces a large instantaneous current. Activated by cAMP. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages.
Immunogen
Fusion protein amino acids 761-863 of rat HCN2, accession number Q9JKA9