Application
Immunohistochemistry: Factor Inhibiting HIF-1 Antibody [ - Detection of FIH-1 in rat brain tissue.Application
Western Blot: Factor Inhibiting HIF-1 Antibody [ - Detection of FIH-1 in rat and human samples| Product Name | HIF1AN antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal to HIF1AN (Factor Inhibiting HIF-1)Factor Inhibiting HIF1 (FIH1 or HIF1AN) protein facilitates repression of HIF-1 transcriptional activity by binding to VHL, which acts as a transcriptional corepressor. VHL inhibits HIF-1 alpha transactivation function by recruiting histone deacetylases. Involvement of VHL in association with FIH provides a unifying mechanism for the modulation of HIF-1 alpha protein stabilization and transcriptional activation in response to changes in cellular oxygen concentration. |
| Immunogen | A C-terminal region synthetic peptide made to the human HIF1AN protein sequence (between residues 300 and the C-terminus). |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | EMICC/IFIHCIHC-PIPWB |
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Electron Microscopy: |
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| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml (Please refer to the vial label for the specific concentration) |
| Gene Synonyms | DKFZp762F1811 FIH1 FLJ20615 FLJ22027 |
|---|---|
| Target | HIF1AN |
| Tissue Specificity | This antibody is specific for HIF1AN protein. |
Application
Immunohistochemistry: Factor Inhibiting HIF-1 Antibody [ - Detection of FIH-1 in rat brain tissue.
Application
Western Blot: Factor Inhibiting HIF-1 Antibody [ - Detection of FIH-1 in rat and human samples| Positive Control | Rat astrocytes and C6 and U251 gliomas |
|---|---|
| Application Notes |
Electron Microscopy: |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at 4 degrees Celcius. |
| Storage Buffer | 0.1 ml of purified antibody [1 mg/ml]in Tris-citrate/phosphate [pH 7-8] buffer containing 0.1% Sodium Azide. |
