Application
Western Blot: Histamine receptor H3 Antibody [ Extracts from hela and raw 264.7 cells.Application
Western Blot: Histamine H3 Receptor Antibody [ - Western blot (WB) analysis of Histamine H3 Receptor (P326) antibody in extracts from COLO205 cells| Product Name | Histamine H3 Receptor antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal antibody to Histamine H3 ReceptorHistamine is an inflammatory mediator that is ubiquitously expressed and has a broad range of pharmacologic effects. Specifically, it plays a role in the central nervous, gastrointestinal, respiratory and immune systems. The effects of histamine are mediated by a family of G protein-coupled receptors,the Histamine H1, H2, H3 and H4 Receptors. The gene encoding the human Histamine H3 Receptor is located on chromosome 20 and is expressed as six alternative splice variants in thalamus. These isoforms contain either a deletion in the second transmembrane domain or a variable deletion in the third intracellular loop. The existence of multiple H3 Receptor isoforms suggests that H3-mediated effects may be regulated through alternative splicing mechanisms.The H3 Receptor acts as an autoreceptor in the central nervous system (CNS) and modulates histamine synthesis and release. It also acts as a heteroreceptor in the CNS and cardiovascular, gastrointestinal and respiratory systems to regulate the release of a variety of neurotransmitters. The Histamine H3 Receptor responds to several agonists and antagonists, which make it a potential therapeutic target for several diseases, such as asthma, epilepsy and cardiac ischemia. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAWB |
| We recommend the following starting dilutions: ELISA 1:1000-1:5000, Western Blot 1:500-1:1000,. Optimal concentration should be determined experimentally by the end user.: |
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| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml (Please refer to the vial label for the specific concentration) |
| Purification | Affinity purified |
| Gene Synonyms | G protein-coupled receptor 97 GPCR97 histamine receptor H3antibody G proteincoupled receptor97 1125585268 G proteincoupled receptor 97 HGNC:5184 HH3Rantibody HRH3 11255 85268 G protein coupled receptor 97 |
|---|---|
| Target | Histamine H3 Receptor |
| Tissue Specificity | Histamine H3 Receptor (P326) detects endogenous levels of Histamine H3 Receptor protein. |
Application
Western Blot: Histamine receptor H3 Antibody [ Extracts from hela and raw 264.7 cells.
Application
Western Blot: Histamine H3 Receptor Antibody [ - Western blot (WB) analysis of Histamine H3 Receptor (P326) antibody in extracts from COLO205 cells| Application Notes | We recommend the following starting dilutions: ELISA 1:1000-1:5000, Western Blot 1:500-1:1000,. Optimal concentration should be determined experimentally by the end user.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Storage Buffer | Phosphate buffered saline, pH 7.2. |
