| Product Name | HLA-DR antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal [423L] to HLA DRHLA DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of an alpha chain (36 kDa) and a beta chain (27 kDa). It is expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells and activated T lymphocytes. Three loci, DR, DQ and DP, encode the major expressed products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides and present them to T-helper cells. They therefore have a critical role in the initiation of the immune response. |
| Immunogen | Tissue / cell preparation (Human). Human lymphoblast B-cell line RPMI 8866, exact epitope not determined. |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG2a |
| Clone Number | 423L |
| Host Species | Mouse |
| Tested Applications | FACSICC/IF |
| FACS: Use at an assay dependent dilution. Optimal dilutions/concentrations should be determined by the end user.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml (Please refer to the vial label for the specific concentration) |
| Purification | Protein A |
| Gene Synonyms | HLADRA1 Major histocompatibility complex class II DR alpha HLADRB MHC class II antigen DRA DR alpha chain precursor MHC II HLADR HLA class II histocompatibility antigen HLA DR |
|---|---|
| Target | HLA-DR |
| Cellular Localization | Type I membrane protein |
| Light Chain Type | kappa |
| Application Notes | FACS: Use at an assay dependent dilution. Optimal dilutions/concentrations should be determined by the end user.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles. |
| Storage Buffer | Preservative: 0.08% Sodium Azide. Constituents: PBS |
