Mouse Monoclonal antibody [4F4] to hnRNP-C1/C2The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. hnRNP C1 and C2 are encoded by one gene; the two alternatively spliced transcript variants have been described.
Immunogen
RNP’s eluted from oligo (dT) cellulose column
Key Feature
Clonality
Monoclonal
Isotype
IgG1
Clone Number
4F4
Host Species
Mouse
Tested Applications
ELISAICC/IFIPWB
For WB: Use at 1:100,000:
Species Reactivity
HumanMonkey
Concentration
1mg/ml (Please refer to the vial label for the specific concentration)
Purification
Protein A
Target Information
Gene Synonyms
hnRNP C hnRNPC
Target
hnRNP-C1/C2
Tissue Specificity
This antibody recognizes the two hnRNP C proteins of 41kDa (C1) and 43kDa (C2) in human cells, and the corresponding proteins in monkey hamster & chicken. Does cross react with mouse in IP, but not IB
Cellular Localization
Component of ribonucleosomes.
Application Notes
For WB: Use at 1:100,000:
Additional Information
Form
Liquid
Storage Instructions
Store at 2-8°C. For extended storage, aliquot and store at -20°C. Avoid repeated freeze-thaw cycles.