| Product Name | ICAM1 / CD54 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal [P1W16] to ICAM1ICAM1 is a 85-110 kDa single-chain type 1 integral membrane glycoprotein with an extracellular domain of five immunoglobulin superfamily repeats, a transmembrane region and a cytoplasmic domain. It shares considerable amino acid sequence homology with ICAM3 and with ICAM2. ICAM1 is expressed by activated endothelial cells. It is detected on cells of many other lineages (e.g. epithelial cells, fibroblasts, chondrocytes, B lymphocytes, T lymphocytes (low), monocytes, macrophages, dendritic cells and neutrophils, with lower levels that increase in inflammation. Also, ICAM1 is detected in some carcinoma and melanoma cells. Soluble ICAM1 is detectable in the plasma and is elevated in patients with various inflammatory syndromes. It is the receptor for rhinoviruses and malaria. |
| Immunogen | Cell preparation: V(+)B2- Human Ocular melanoma line. |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | P1W16 |
| Host Species | Mouse |
| Tested Applications | FACSICC/IFIHC-PIP |
| FACS: Use at an assay dependent dilution. IF: Use at an assay dependent dilution. IHC-P: Use at an assay dependent dilution. IP: Use at an assay dependent dilution. Optimal dilutions/concentrations should be determined by the end user.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | Major group rhinovirus receptor BB2 intercellular adhesion molecule 1 cell surface glycoprotein P3.58 CD54 human rhinovirus receptor ICAM1 intercellular adhesion molecule1 P3.58 |
|---|---|
| Target | ICAM1 |
| Tissue Specificity | P1W16 may be useful for prognosis of malignant melanoma. |
| Cellular Localization | Type I membrane protein |
| Positive Control | Positive control lysate: A375M melanoma cell line or tonsil 85-115 kDa MW |
|---|---|
| Application Notes | FACS: Use at an assay dependent dilution. IF: Use at an assay dependent dilution. IHC-P: Use at an assay dependent dilution. IP: Use at an assay dependent dilution. Optimal dilutions/concentrations should be determined by the end user.: |
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles. |
| Storage Buffer | Preservative: None. Constituents: PBS |
