| Product Name | IL1 beta antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal antibody [4M27] to IL1 betaThe protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008] |
| Immunogen | Human recombinant IL-1 beta |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG2 |
| Clone Number | 4M27 |
| Host Species | Mouse |
| Tested Applications | IHCNeutWB |
| WB(1:500-2000)|IHC (frozen)(1:20-100)|Neutralization of IL-1 beta bioactivity: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | IL1F2 interleukin 1 beta IL1-BETA IL-1 IL1B |
|---|---|
| Target | IL1 beta |
| Tissue Specificity | This antibody was selected for its ability to detect human IL-1 beta. |
| Application Notes | WB(1:500-2000)|IHC (frozen)(1:20-100)|Neutralization of IL-1 beta bioactivity: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | PBS |
