Rabbit polyclonal antibody to IL10The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.[provided by RefSeq, May 2011]
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
ELISAIHC-PWB
P-ELISA:1:500-1000, WB:1:100-500, IHC-P:1:100-500 (based on 0.5 mg/ml):
Species Reactivity
HumanMouseDogPigRat
Concentration
0.5mg/ml
Purification
Affinity purified
Target Information
Gene Synonyms
CSIF interleukin 10 IL-10 IL10A TGIF GVHDS
Target
IL10
Application
Application
IHC-P analysis of dog ureter tissue using IL-10 antibody.
Application
IHC-P analysis of human colon tissue using IL-10 antibody.
Application Notes
P-ELISA:1:500-1000, WB:1:100-500, IHC-P:1:100-500 (based on 0.5 mg/ml):
Additional Information
Form
Liquid
Storage Instructions
Store at 4°C for up to two weeks. For long term storage, aliquot and store at -20°C, avoid freeze/thaw cycles.
Storage Buffer
10 mM PBS, pH 7.4 with 10 mg/ml BSA and 0.1% sodium azide