| Product Name | IL12 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal antibody [7M58] to IL-12This gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity. [provided by RefSeq, Jul 2008] |
| Immunogen | Human recombinant IL-12 |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | 7M58 |
| Host Species | Mouse |
| Tested Applications | ELISAIHC |
| WB(1:500-2000)|IHC (frozen)(1:20-100)|Neutralization of IL-12 bioactivity: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | CLMF IL-12A P35 IL12A interleukin 12A (natural killer cell stimulatory factor 1 cytotoxic lymphocyte maturation factor 1 p35) NKSF1 NFSK |
|---|---|
| Target | IL-12 |
| Tissue Specificity | This antibody was selected for its ability to detect human IL-12. |
| Application Notes | WB(1:500-2000)|IHC (frozen)(1:20-100)|Neutralization of IL-12 bioactivity: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | PBS |
