| Product Name | IL4 Receptor / CD124 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal antibody [4Y44] to IL-4R alphaThis gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012] |
| Immunogen | Human recombinant IL-4R alpha EC domain |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG2 |
| Clone Number | 4Y44 |
| Host Species | Mouse |
| Tested Applications | IHCNeutWB |
| WB(1:500-1000)|IHC (paraffin)(1:20-200)|Neutralization of IL-4R alpha mediated signaling: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | IL4R interleukin 4 receptor IL-4RA IL4RA CD124 |
|---|---|
| Target | IL-4R alpha |
| Tissue Specificity | This antibody was selected for its ability to detect human IL-4R alpha. |
| Application Notes | WB(1:500-1000)|IHC (paraffin)(1:20-200)|Neutralization of IL-4R alpha mediated signaling: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | PBS |
