| Product Name | Involucrin antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal [SY8] to InvolucrinInvolucrin, a component of the keratinocyte crosslinked envelope, is found in the cytoplasm and crosslinked to membrane proteins by transglutaminase. Involucrin is expressed in a range of stratified squamous epithelia, including the cornea. In normal epidermis, it is first expressed in the upper spinous layers, and in keratinocyte cultures it is expressed by all cells that have left the basal layer. Involucrin expression is abnormal in squamous cell carcinomas and premalignant lesions and is reduced in severe dysplasias of the larynx and cervix. Its gene is mapped to 1q21, among calpactin I light chain, trichohyalin, profillaggrin, loricrin, and calcyclin. |
| Immunogen | Pure involucrin from human keratinocytes. |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | SY8 |
| Host Species | Mouse |
| Tested Applications | IHC-PIPWB |
| IHC-P: Use at an assay dependent dilution. IP: Use at an assay dependent dilution. WB: Use at an assay dependent dilution. Predicted molecular weight: 68 kDa. Optimal dilutions/concentrations should be determined by the end user.: |
|
| Species Reactivity | HumanDogMonkeyPigGorillaOwl |
| Concentration | 1mg/ml (Please refer to the vial label for the specific concentration) |
| Purification | Protein G |
| Gene Synonyms | ivl Involucrin |
|---|---|
| Target | Involucrin |
| Tissue Specificity | Keratinocytes of epidermis and other stratified squamous epithelia |
| Cellular Localization | Cytoplasmic |
| Application Notes | IHC-P: Use at an assay dependent dilution. IP: Use at an assay dependent dilution. WB: Use at an assay dependent dilution. Predicted molecular weight: 68 kDa. Optimal dilutions/concentrations should be determined by the end user.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles. |
| Storage Buffer | Preservative: None. Constituents: PBS |
