| Product Name | KIR2DS4 antibody [2G42] |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal antibody [2G42] to KIR2DS4Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are |
| Immunogen | Human recombinant KIR2DS4 |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG2 |
| Clone Number | 2G42 |
| Host Species | Mouse |
| Tested Applications | FACSWB |
| FC(1:50-100)|WB(1:500-1000) | |
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4 , KKA3 , CD158I , NKAT8 , KIR412 , KIR1D |
|---|---|
| Target | KIR2DS4 |
| Tissue Specificity | This antibody was selected for its ability to specifically detect human KIR2DS4. |
| Application Notes | FC(1:50-100)|WB(1:500-1000) |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | PBS |
