| Product Name | L1CAM antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal [UJ127.11] to L1CAMThe L1CAM gene, which is located in Xq28, is involved in three distinct conditions: 1) HSAS (hydrocephalus-stenosis of the aqueduct of Sylvius); 2) MASA (mental retardation, aphasia, shuffling gait, adductus thumbs); and 3) SPG1 (spastic paraplegia). The L1, neural cell adhesion molecule (L1CAM) also plays an important role in axon growth, fasciculation, neural migration and in mediating neuronal differentiation. Expression of L1 protein is restricted to tissues arising from neuroectoderm. |
| Immunogen | Tissue preparation: Homogenous suspension of human fetal brain |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | UJ127.11 |
| Host Species | Mouse |
| Tested Applications | FACSIHCIPWB |
| IP: Use at an assay dependent dilution. WB: a working concentration of 0.25-0.5 mg/mL is recommended using cell extracts of G361 cells (human melanoma).Predicted molecular weight: 140 kDa. Optimal dilutions/concentrations should be determined by the end user.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | S10 CD171 HSAS1 MIC5 L1 cell adhesion molecule L1CAM antigen identified by monoclonal antibody R1 SPG1 NEURAL CELL ADHESION MOLECULE L1 PRECURSOR MASA N CAML1 HGNC:7086 CAML1 HSAS N-CAM-L1 N-CAML1 NCAM-L1 NCAM L1 N CAM L1 NCAML1 |
|---|---|
| Target | L1CAM |
| Tissue Specificity | UJ127.11 may be useful in the diagnosis of embryonic tumours (e.g. neuroblastoma). |
| Cellular Localization | Cell Membrane |
| Application Notes | IP: Use at an assay dependent dilution. WB: a working concentration of 0.25-0.5 mg/mL is recommended using cell extracts of G361 cells (human melanoma).Predicted molecular weight: 140 kDa. Optimal dilutions/concentrations should be determined by the end user.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles. |
| Storage Buffer | Preservative: 15 mM Sodium Azide. Constituents: 0.01 M PBS, pH 7.4 |
