| Product Name | LAMP1 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal antibody [B-T47] to LAMP1CD107a (lysosome-associated membrane protein-1, LAMP-1), together with LAMP-2, is a major constituent of lysosomal membrane, 1-2% of total CD107a is found also on the plasma membrane. The LAMP proteins are involved in lysosome biogenesis and are required for fusion of lysosomes with phagosomes. Increased CD107a immunoreactivity is observed in neurones, and in glial cells surrounding senile plaques in Alzheimers disease cases and is localized mainly in medullary epithelial cells, single macrophages and lymphocytes in acute thymic involution. CD107a is a good marker of mast cell activation.Entrez Gene: 13q34 |
| Immunogen | U937 human Caucasian hystiocytic lymphoma cell line |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | B-T47 |
| Host Species | Mouse |
| Tested Applications | FACSICC/IFIHC-P |
| Flow Cytometry:1 μg/ml IHC-P,ICC/IF:Use at an dependent assay.GTX80229 does not contain sodium azide and could potentially be used for functional studiesOptimal dilutions should be determined experimentally by the researcher.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | CD107a LAMPA LGP120 LAMP1 LAMP-1 |
|---|---|
| Target | LAMP1 |
| Tissue Specificity | The antibody B-T47 recognizes CD107a, a 100-120 kDa glycoprotein expressed mainly on lysosomal, but also on the plasma membrane. |
| Cellular Localization | This protein shuttles between lysosomes, endosomes, and the plasma membrane. |
| Application Notes | Flow Cytometry:1 μg/ml IHC-P,ICC/IF:Use at an dependent assay.GTX80229 does not contain sodium azide and could potentially be used for functional studiesOptimal dilutions should be determined experimentally by the researcher.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at 2-8°C. Do not use after expiration date stamped on vial label. For long-term storage aliquot and store at -20°C. Avoid freeze/thaw cycles. |
| Storage Buffer | Azide free phosphate buffered saline (PBS), approx. pH 7.4; 0.2 μm filter sterilized. |
