| Product Name | Low Density LRP antibody [8G1] |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal [8G1] to Low Density LRPMost abundant in liver, brain and lung. Involved in the plasma clearance of chylomicron remnants and activated alpha 2 macroglobulin, as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. After cleavage, the intracellular domain (LRPICD) is detected both in the cytoplasm and in the nucleus. The LRPICD is involved in the interaction with MAFB. Cleaved into a 85 kDa membrane spanning subunit (LRP-85) and a 515 kDa large extracellular domain (LRP-515) that remains non covalently associated. |
| Immunogen | Human LRP/alpha2 MR. |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | 8G1 |
| Host Species | Mouse |
| Tested Applications | BlockingFACSICC/IFIHC-FIHC-PWB |
| Recommended dilutions: Dot: Use at an assay dependent dilution. FACS: Use at an assay dependent dilution. IHC-Fr: Use at a concentration of 1 - 10 μg/ml. IHC-P: Use at a concentration of 1 - 10 μg/ml. WB: Use at a concentration of 1 - 5 μg/ml. Use under non reducing conditions. Optimal dilutions/concentrations should be determined by the end | |
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Protein A |
| Gene Synonyms | 107770, Q07954, LRP, TGFBR5, 4035, APOER, LRP1, A2MR, APR, CD91, MGC88725, Low Density LRP |
|---|---|
| Target | Low Density LRP |
| Tissue Specificity | Specifically reacts with the 515kDa alpha chain of LRP/alpha2 MR expressed in hepatocytes, tissue macrophages, subsets of neurons and astrocytes in the CNS, fibroblasts, smooth muscle cells and monocyte derived foam cells in atherosclerotic lesions of arterial walls. |
| Cellular Localization | Type I membrane protein. |
| Light Chain Type | kappa |
| Application Notes | Recommended dilutions: Dot: Use at an assay dependent dilution. FACS: Use at an assay dependent dilution. IHC-Fr: Use at a concentration of 1 - 10 μg/ml. IHC-P: Use at a concentration of 1 - 10 μg/ml. WB: Use at a concentration of 1 - 5 μg/ml. Use under non reducing conditions. Optimal dilutions/concentrations should be determined by the end |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles. |
| Storage Buffer | Preservative: None. Constituents: 50mM Sodium phosphate, 100mM Sodium chloride. pH 7.4 |
