| Product Name | MAGE 1 antibody [E22-11B2-E9] |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal [E22 - 11B2 - E9] to MAGE 1Human malignant neoplasms carry rejection antigens that are recognized by the patient's autologous, tumor directed and specific, cytolytic, CD8+ T lymphocyte clones (CTL). An important group of antigens is coded by the MAGE family of genes. It was identified that melanomas and primary glial brain tumors express common melanoma associated antigens (MAAs). Because MAGE 1 is expressed on a significant proportion of human neoplasms of various histological types (melanoma, brain tumors of glial origin, neuroblastoma, non-small cell lung cancer, breast, gastric, colorectal, ovarian, renal cell carcinomas) and not on normal tissues, the encoded antigen may serve as a marker of early detection and target for cancer immunotherapy. |
| Immunogen | Recombinant full length protein (Human). |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG2a |
| Clone Number | E22-11B2-E9 |
| Host Species | Mouse |
| Tested Applications | WB |
| Western Blotting: use at a concentration of 1 - 2μg / ml for 2hrs at RT. Optimal dilutions / concentrations should be determined by the end user. By Western blot, this antibody detects a band of 42 - 46 kDa, which corresponds to the predicted molecular weight of MAGE 1. | |
| Species Reactivity | Human |
| Concentration | 0.2mg/ml |
| Purification | Protein A |
| Gene Synonyms | MAGEA1 Melanoma Antigen Melanoma Associated Antigen MZ2-E, MAGE 1, MAGE1, MAGEA1 Melanoma Antigen Melanoma Associated Antigen MZ2E, CT1.1, MGC9326 |
|---|---|
| Target | MAGE 1 |
| Cellular Localization | Cell Membrane |
| Application Notes | Western Blotting: use at a concentration of 1 - 2μg / ml for 2hrs at RT. Optimal dilutions / concentrations should be determined by the end user. By Western blot, this antibody detects a band of 42 - 46 kDa, which corresponds to the predicted molecular weight of MAGE 1. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution, aliquot and store at 4°C. Do not freeze. |
| Storage Buffer | 10mM PBS, pH7.4 containing 0.2%BSA, 0.09% sodium azide |
