Application
IHC analysis of human tonsil tissue using Mast cell tryptase antibody [AA1].| Product Name | Mast cell tryptase antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal antibody [AA1] to Mast cell tryptaseTryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, alpha and beta 1. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas i |
| Immunogen | Human mast cell tryptase purified from human lung tissue. |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | AA1 |
| Host Species | Mouse |
| Tested Applications | ELISAICC/IFIHCIHC-FIHC-PWB |
| Immunohistology - Paraffin: Max Dilution 1/10,000 Optimal dilution / concentration should be determined by the end user.: |
|
| Species Reactivity | HumanDogMonkeyRatCat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | TPSB1 TPS1 tryptase alpha/beta 1 TPS2 TPSAB1 |
|---|---|
| Target | Mast cell tryptase |
| Tissue Specificity | This antibody recognizes human mast cell tryptase, both alpha and beta isoforms. |
Application
IHC analysis of human tonsil tissue using Mast cell tryptase antibody [AA1].| Application Notes | Immunohistology - Paraffin: Max Dilution 1/10,000 Optimal dilution / concentration should be determined by the end user.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4°C or at -20°C if preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. |
| Storage Buffer | Phosphate buffered saline containing 0.09% Sodium Azide |
