Mouse Monoclonal Antibody [4D1E2] to MMP2Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Immunogen
The immunogen corresponding to a region within amino acids 242 and 396 of human MMP2 expressed in E. Coli.
Key Feature
Clonality
Monoclonal
Isotype
IgG1
Clone Number
4D1E2
Host Species
Mouse
Tested Applications
ELISAWB
ELISA: 1/10000.:
Species Reactivity
Human
Concentration
1mg/ml (Please refer to the vial label for the specific concentration)
Target Information
Gene Synonyms
MONA CLG4 CLG4A TBE-1 MMP-II
Target
MMP2
Molecular Weight(MW)
73.8 kDa (note)
Application
Application
WB analysis of A431 cell lysate using MMP2 antibody [4D1E2].
Application
ELISA analysis using MMP2 antibody [4D1E2] and either antigen protein or a negative control protein.
Application Notes
ELISA: 1/10000.:
Additional Information
Form
Liquid
Storage Instructions
4°C; -20°C for long term storage
Storage Buffer
Purified antibody in PBS with 0.05% sodium azide and 0.5% protein stabilizer.