Application
Western blot analysis of MMS21 in 293 cell lysate with MMS21 antibody at (A) 0.5 and (B) 1 ug/ml.| Product Name | MMS21 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal antibody to MMS21MMS21, also known as NSE2, is a SUMO ligase that in combination with the SMC5/6 complex is required for the prevention of DNA damage induced apoptosis by facilitating DNA repair in human cells. MMS21-dependent sumoylation is integral and important to the cohesion mechanism and mitotic progression; this function appears to be independent of SMC6. MMS21 mediates SUMO attachment to various proteins such as SMC6L1 and TRAX, and possibly the cohesin components RAD21 and STAG2. |
| Conjugation | Agarose |
| Modification | Acetylated |
| Clonality | Polyclonal |
|---|---|
| Isotype | Cocktail |
| Host Species | Rabbit |
| Tested Applications | ELISAIHCWB |
| IHC:1:50~1:200 WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | Non-SMC element 2 NonSMC element2 NonSMC element 2 NSMCE2 MMS21 homolog E3 SUMO-protein ligase NSE2 MMS21 E3 SUMOprotein ligase NSE2 Non SMC element 2 E3 SUMO protein ligase NSE2 |
|---|---|
| Target | MMS21 |
| Tissue Specificity | This antibody is specific for MMS21 |
Application
Western blot analysis of MMS21 in 293 cell lysate with MMS21 antibody at (A) 0.5 and (B) 1 ug/ml.| Positive Control | Blocking Peptide: Cat.No. GTX85185-PEP - MMS21 Peptide Lysates: Cat. No. GTX27902 - 293 Cell Lysate |
|---|---|
| Application Notes | IHC:1:50~1:200 WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | PBS containing 0.02% sodium azide |
