Application
Western blot analysis of MPYS in A-20 cell lysate with MPYS antibody at (A) 1 and (B) 2 ug/ml.Application
Immunocytochemistry of MPYS in A20 cells with MPYS antibody at 5 ug/ml.Application
Immunofluorescence of MPYS in A20 cells with MPYS antibody at 20 ug/mL.| Product Name | MPYS antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal antibody to MPYSMPYS is a recently identified plasma membrane tetraspanner that is associated with major histocompatibility complex class II (MHC-II) and mediates its transduction of apoptotic signals. It has also been found to be associated with VISA, a mitochondrial protein that acts as an adaptor in virus-triggered signaling. MPYS also interacts with IRF3 and recruits the kinase TBK1 to the VISA-associated complex, acting as a critical mediator of virus-triggered IRF3 activation and interferon (IFN) expression. It is thought that the binding of nucleic acid to the innate immune protein RIG-I causes complex formation between RIG-I, VISA, and MPYS. This complex then recruits TBK1 to phosphorylate IRF3 which then directly activates IFN transcription. At least three isoforms of MPYS are known to exist. |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | ELISAICC/IFWB |
| ICC/IF:1:200~1:500 WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | Transmembrane protein173 MITA STING ERIS MPYS Transmembrane protein 173 TMEM173 |
|---|---|
| Target | MPYS |
| Tissue Specificity | This antibody is specific for MPYS |
Application
Western blot analysis of MPYS in A-20 cell lysate with MPYS antibody at (A) 1 and (B) 2 ug/ml.
Application
Immunocytochemistry of MPYS in A20 cells with MPYS antibody at 5 ug/ml.
Application
Immunofluorescence of MPYS in A20 cells with MPYS antibody at 20 ug/mL.| Positive Control | Blocking Peptide: |
|---|---|
| Application Notes | ICC/IF:1:200~1:500 WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | PBS containing 0.02% sodium azide |
