| Product Name | MRP1 antibody [QCRL3] |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal [QCRL3] to MRP1The MRP molecule (190 kDa), an integral membrane glycophosphoprotein belonging to the same superfamily of ATP-binding cassette transmembrane transporter proteins as P-glycoprotein, is overexpressed in many P-glycoprotein-negative, multidrug resistant cell lines and tumors. It is believed that the main function of MRP in drug resistance is that of a plasma membrane drug efflux pump. |
| Immunogen | Membranes prepared from the human small cell lung cancer cell line H69AR which highly overexpresses MRP |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG2a |
| Clone Number | QCRL3 |
| Host Species | Mouse |
| Tested Applications | IHC |
| IHC: Use at an assay dependent dilution. Optimal dilutions/concentrations should be determined by the end user. | |
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Unpurified |
| Gene Synonyms | ABC29, GSX, P33527, ABCC1, 158343, GS-X, ABCC, MRP1, DKFZp781G125, 4363, MRP, GS X |
|---|---|
| Target | MRP1 |
| Tissue Specificity | This antibody detects a 190 kDa transmembrane phosphoglycoprotein overexpressed in various hummation dependent multidrug resistant tumor cell lines. It does not cross react with human MDR1 and MDR3, or mouse MRP gene products. |
| Cellular Localization | Cell Membrane |
| Positive Control | Cell Lines: Drug sensitive parental cell lines and their multidrug resistant derivatives |
|---|---|
| Application Notes | IHC: Use at an assay dependent dilution. Optimal dilutions/concentrations should be determined by the end user. |
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution, aliquot and store at 4°C. |
| Storage Buffer | Preservative: 0.1% Sodium Azide; Constituents: 1% BSA, 0.01M PBS |
