| Product Name | Myosin VIIa antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit anti-Myosin-VIIa polyclonal antibodyMyosin-VIIa is one of the unconventional members of the myosin molecular motor superfamily that move along filamentous actin. The protein is expressed primarily in the inner ear, retina and testis. Defects in the myosin-VIIa gene (MYO7A) are responsible for Usher syndrome, characterized by hearing impairment, lack of vestibular function and progressive retinal degeneration.MYO7A mutations are are responsible for deafness in shaker-1 mice and in other model systems. In the inner ear, myosin-VIIa is required for assembly of stereocilia, the sensory structures necessary for detecting sound signals. |
| Immunogen | Rabbits were immunized with amino acids 880-1077 from the tail region of human myosin-VIIa. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ICC/IFWB |
| IF (5-10 ug/ml), WB (0.5-1.0 ug/ml): |
|
| Species Reactivity | Human |
| Concentration | 0.5mg/ml |
| Gene Synonyms | DFNA11 DFNB2 MYOVIIA MYU7A NSRD2 USH1B |
|---|---|
| Target | Myosin VIIa |
| Application Notes | IF (5-10 ug/ml), WB (0.5-1.0 ug/ml): |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at -20° C. Avoid multiple freeze/thaw cycles. |
| Storage Buffer | 50 ug (0.38 mg/ml) of affinity purified IgG with 50% glycerol, 0.01% sodium azide and 1.0 mg/ml BSA. |
